Creating Mini-Pigs for Human Organ Transplants

Monday, April 27, 2009
(photo: Wolf Den's Zoo)

Pigs hardly resemble the gallant heroes featured in movies and comic books. By 2017, however, “mini-pigs” may be saving more lives than Spiderman ever has, shining a new “bacon of hope” for those on the organ transplant waitlist by providing their pancreas islet cells, heart valves and hearts. Of the 100,000 people currently in line for an organ transplant, many will die waiting. In the United States alone, in recent years 6,000 people have died annually for lack of human organs. The line is expected to grow even longer, to an estimated 1.58 million people by 2015. The transplanting of animal organs into humans has been stymied by the fact that human bodies recognize the organ as foreign and reject it in a matter of minutes to hours.

 
Scientists at Korea Biotech Research and Development have successfully produced the clone of a miniature swine that has been genetically modified to lack one of two genes that cause the human rejection of pig organs. This is the second birth of its kind, bringing the world closer to the possibility of pig-to-human transplants. In a joint project with several institutions, Korea Biotech R&D aims for mass production of these specially cloned piglets and commercialization of their organs.
 
The first successful birth of such mini-pigs was accomplished by researchers led by Randall Prather at the University of Missouri-Columbia. A piglet’s organs were transplanted into a baboon with no rejection.
-Vivian Kim
 
‘Mini-pig’ a Promising Sign for Transplants (by Seo Ji-eun, JoongAng Daily)
A Bacon of Hope (by Sean Powers, SyndicateMizzou)

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